Abstract
[m . 2]Metacyclophanes with an oxo-function in the C2 bridge exhibit an enhanced carbonyl reactivity towards nucleophiles. The equilibrium constants for hydration and hemiacetal formation markedly decrease asm increases and qualitatively correlate with the ring strain present in the parent hydrocarbon. [m . n]Metacyclophanes withm,n ≥ 3 are almost free from intraanular steric strain. Accordingly, oxo-functions in the bridges do not exhibit an appreciable enhancement of reactivity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
