Abstract
Daily adequate water intake to maintain euhydration is arguably the most important nutrient requirement for humans. Within a margin of error, the body regulates the maintenance of body fluid balance and especially that of the plasma volume, through mechanisms that stimulate thirst and/or modify the rate of urine production. However, there are circumstances such as with excessive sweating during exercise in the heat, osmotic diarrhea, or excessive fluid consumption, or water intoxication where normal mechanisms of regulation may be inadequate to compensate for acute changes in hydration status and result in life threatening consequences. Health and onset of disease may be affected by the chronic hydration state of individual. The risks of colorectal cancer, nephrolithiasis in those with a history of kidney stones, and bladder cancer may be reduced by more frequent water consumption. Recent research suggests that appropriate timing of water intake around meal occasions may help reduce energy intake and contribute to maintenance of body weight in overweight individuals. Definitive benefits of hydration on cardiovascular and oral health and general immune system function remain to be determined. It is also unclear whether the health benefits of water and fluid ingestion are a function of the process of frequent fluid intake or the maintenance of a potentially expanded state of hydration.
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