Abstract
Nucleolus-associated DNA was isolated from SV40-transformed Chinese hamster cell lines, and hybridized with SV40 [ 3H]cRNA to determine whether a unique integration site could be selectively fractionated between nucleoli and total nuclear DNA. The distribution pattern of integrated SV40 genomes between these two DNA fractions varied from clone to clone. These results are consistent with multiple sites of integration of SV40 DNA into Chinese hamster cell DNA.
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