Abstract
Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g−1 for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.
Highlights
The combination of materials comes from the need for better performance and properties in order to improve those observed in the precursor materials, aiming for application optimization and innovation
Organic-inorganic hybrid materials are investigated to improve existing the use of phyllosilicates, which is justified because these materials are abundant in nature, are low properties of starting materials, aiming to have a better interaction with the drug and promote its cost,controlled non-toxic, and have the ability to adsorb ions and/or molecules in their interlamellar space release in the organism [5,6,7,8,9]
InDifferent addition, there isforthe potential diversity of theirinuse, is due to have the ease with which materials controlled release are reported the which literature, which in common thesethe materials are modifiedwhich use of phyllosilicates, is justified because these materials are abundant in nature, are low Phyllosilicates may interact with giving to a new mineral-polymer matrix cost, non-toxic, and have the ability tochitosan, adsorb ions and/orrise molecules in their interlamellar space
Summary
The combination of materials comes from the need for better performance and properties in order to improve those observed in the precursor materials, aiming for application optimization and innovation. Organic-inorganic hybrid materials are investigated to improve existing the use of phyllosilicates, which is justified because these materials are abundant in nature, are low properties of starting materials, aiming to have a better interaction with the drug and promote its cost,controlled non-toxic, and have the ability to adsorb ions and/or molecules in their interlamellar space release in the organism [5,6,7,8,9]. These can control release by dispersing the drug These matrices are a type of material that is studied extensively for drug delivery systems due to contained within or adsorbed to the surface of a porous polymer or mineral matrix [22,25,26]. The inorganic-organic hybrid formed between these matrices (Talc + Ch) in order to evaluate its
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