Abstract
Hybrid positron emission tomography–magnetic resonance (PET-MR) imaging is a novel imaging modality with emerging applications for cardiovascular disease. PET-MR aims to combine the high-spatial resolution morphological and functional assessment afforded by magnetic resonance imaging (MRI) with the ability of positron emission tomography (PET) for quantification of metabolism, perfusion, and inflammation. The fusion of these two modalities into a single imaging platform not only represents an opportunity to acquire complementary information from a single scan, but also allows motion correction for PET with reduction in ionising radiation. This article presents a brief overview of PET-MR technology followed by a review of the published literature on the clinical cardio-vascular applications of PET and MRI performed separately and with hybrid PET-MR.
Highlights
Positron emission tomography (PET) and magnetic resonance imaging (MRI) are well established modalities for the investigation of cardiovascular disease
This article presents a brief overview of positron emission tomography–magnetic resonance (PET-MR) technology followed by a review of the published literature on the clinical cardio-vascular applications of PET and MRI performed separately and with hybrid PET-MR
In PET-CT, attenuation correction (AC) of PET data is derived from computed tomography (CT) data, which are rescaled from Hounsfield units to 511-keV linear attenuation coefficients to generate robust l-maps.[4]
Summary
Positron emission tomography (PET) and magnetic resonance imaging (MRI) are well established modalities for the investigation of cardiovascular disease. Parametric mapping with MRI allows visualization of quantitative changes in the myocardium based on changes in T1, T2, T2* and allows detection of myocardial fibrosis, infiltration, and inflammation and iron overload.[1] PET allows assessment of physiological processes by labelling biological compounds with positron emitting radionuclides[2] and is the reference standard for non-invasive assessment of myocardial perfusion and absolute myocardial blood flow (MBF), myocardial metabolism, and inflammation. Integrated PET and MRI may confer synergistic value from image co-registration, motion correction, and reduction in ionising radiation for clinical applications. This article presents a brief overview of positron emission tomography–magnetic resonance (PET-MR) technology followed by a review of the published literature on the clinical cardio-vascular applications of PET and MRI performed separately and with hybrid PET-MR
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