Abstract
Surface modifications with organic materials, especially mimicking the “lock and key” model or binding residues of natural enzymes, could improve the substrate selectivity and catalytic activities of nanozymes. Coupling functional nanozymes or combination with natural enzymes offer an inimitable way for engineering artificial catalytic systems with synergetic or even novel properties. The hybrid system integrates the unique features of nanomaterials with advantages of natural enzymes and often leads to totally novel performances of hybrid nanozymes. The hybrid nanozymes represent a shortcut but an intelligent approach to unfold the promising potential of nanozymes in many important applications. Engineering of poly-hybrid systems may open a door for future development of artificial enzymes.
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