Abstract
Molecularly imprinted polymers (MIPs) have been widely used in nanomedicine in the last few years. However, their potential is limited by their intrinsic properties resulting, for instance, in lack of control in drug release processes or complex detection for in vivo imaging. Recent attempts in creating hybrid nanomaterials combining MIPs with inorganic nanomaterials succeeded in providing a wide range of new interesting properties suitable for nanomedicine. Through this review, we aim to illustrate how hybrid molecularly imprinted polymers may improve patient care with enhanced imaging, treatments, and a combination of both.
Highlights
The application of nanotechnologies to medicine, or for short, nanomedicine, is predicted to revolutionize the future of healthcare
The solid-phase synthesis has been employed by other groups [69,70], with attempts to automatize the synthesis process and to improve the binding properties of the molecularly imprinted polymers (MIPs). This process increases the binding properties as non-imprinted nanoparticles are washed before releasing MIPs, less dialysis is required to remove the template and the reusable aspect of the glass beads [71] tends to decrease the cost of this technique
Molecularly imprinted polymers have been mostly used in senso analytical purposes but during the last decade, great developments have been
Summary
The application of nanotechnologies to medicine, or for short, nanomedicine, is predicted to revolutionize the future of healthcare. It is only recently that molecularly imprinted polymers (MIPs) have been used to enhance the targeting properties of nanoparticles Another aspect developed in nanomedicine is the possibility to use nanosized objects to transport and deliver drugs at a given location inside a living body, despite biological barriers and degradation mechanisms. Quantum dots, characterized by excellent stability and specific emission wavelengths depending on their size, 3were of 25 pioneered by Brus’ group [26] This exceptional nanomaterial can be couped to MIPs for useful applications in targeted imaging.
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