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Abstract
Hematopoiesis is a complex process which results in production of erythrocytes, platelets and white blood cells from pluripotent stem cells located in the bone marrow. We will present hybrid models of hematopoiesis and will use them to study the lineage choice of bipotent erythro-megakaryocytic progenitors and erythroid lineage of hematopoiesis. Biological cells will be considered as individual objects, intracellular regulatory networks will be described with ordinary differential equations and biochemical substances in the extracellular matrix with partial differential equations.
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