Hybrid‐Increased Radical‐Scavenging Activity of Resveratrol Derivatives by Incorporating a Chroman Moiety of Vitamin E

Abstract

A winning combination: Resveratrol derivatives incorporating a chroman moiety of vitamin E were constructed, resulting in the remarkable enhancement in tris(2,4,6-trichloro-3,5-dinitrophenyl)methyl radical (HNTTM.)-scavenging activity as compared with the parent molecules (see scheme). Reaction kinetic analysis, oxidative product identification, and redox potential determination demonstrate that the reaction is governed by a sequential proton-loss electron-transfer (SPLET) mechanism.