Hybrid immunity protection against severe acute respiratory syndrome coronavirus 2 and severe coronavirus disease 2019 in kidney transplantation: A retrospective, comparative cohort study

Abstract

Hybrid immunity, resulting from a combination of severe acute respiratory syndrome coronavirus 2 infection and vaccination, offers robust protection against coronavirus disease 2019 in the general population. However, its impact on immunocompromised patients remains unexplored. We investigated the effect of hybrid immunity against the Omicron variant in a population of kidney transplant recipients receiving the fourth dose mRNA monovalent vaccination. By extracting data from the clinical records and performing individual interviews, participants were categorized into the hybrid cohort (previously infected and vaccinated individuals) and the vaccine cohort (vaccinated-only individuals). The study comprised 1114 participants, 442 in the hybrid and 672 in the vaccine cohorts. From April 2022 to August 2023, 286 infections, 38 hospitalizations and 9 deaths were reported. The cumulative incidence of infection was 12.1% (95% confidence interval [CI], 9.03-16.03) for the hybrid cohort and 36.54% (95% CI, 32.81-40.54) for the vaccine cohort after 300 days of follow-up. Hybrid immunity was associated to a 72% lower risk of infection (adjusted hazard ratio, 0.28; 95% CI, 0.21-0.38) and a 96% lower risk of hospitalization (adjusted hazard ratio, 0.04; 95% CI, 0.01-0.32). No deaths occurred in the hybrid cohort. Hybrid immunity was associated with a lower incidence of severe acute respiratory syndrome coronavirus 2 infection and severe coronavirus disease 2019, underscoring its importance for risk stratification in this vulnerable patient population.