Abstract
In this study, some hybrid materials based on sodium alginate (NaAlg) and porous clay heterostructures (PCHs) were investigated as new hosts for 5-Fluorouracil (5-FU) encapsulation. The hybrid hosts were prepared by ionotropic gelation technique using different concentrations of PCHs (1, 3, and 10 wt%) in order to identify the optimal parameters for encapsulation and drug release. The obtained hybrid materials were characterized using FTIR Spectrometry, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and UV-Vis spectrometry to investigate the interactions of the raw materials involved in the preparation of hybrid hosts, the influence of PCHs concentrations on drug encapsulation efficiency and drug release profile. All the results show that the synthesized hybrid materials were able to load a high amount of 5-FU, the encapsulation efficiency and the release profile being influenced by the concentrations of PCHs.
Highlights
IntroductionUsuunder the terms and ally, 5-FU is available as an intravenous formulation
Half-life,the and low drug selectivity towards tumors. These results show that the synthesized hybrid materials were able to load a high amount of
The second step was focused on the synthesis of porous clay heterostructures (PCHs) precursors using organically modified MMT that was treated with a precise amount of neutral amine (DDA) and silica precursor (TEOS) in the presence of water
Summary
Usuunder the terms and ally, 5-FU is available as an intravenous formulation This type of administration of 5-FU the Creative Commons is associated with different side effects such as psychological stress, hypertrophy, or atCC BY) license rophy, which cause damage in healthy tissues. Some organic–inorganic hybrid hosts based on NaAlg and PCHs were synthesized and proposed as drug delivery systems for 5-Fluorouracil active substance The performance of these materials as drug delivery systems may be influenced by the interaction between the components involved in the synthesis and the dispersion degree of PCHs within polymeric matrix, and the release of the drug is strongly influenced by the porous texture of PCHs and PCHs content
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