Abstract
Hybrid compounds derived from natural diterpenoid isosteviol and antitubercular drug isoniazid (isonicotinic acid hydrazide) and its isomers (nicotinic and 2-picolinic acid hydrazides) were synthesized, and their structure in crystal and in solution was studied. The newly synthesized compounds were found to inhibit Micobacterium tuberculosis (H37RV strain) in vitro, the minimal inhibitory concentration being 10–20 μg/ml.
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