Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Felipe Ladeira De Oliveira,Alice De Miranda Machado,José Augusto Da Costa Nery,Luisa Kelmer Côrtes De Barros Silveira

doi:10.1155/2012/102915

Felipe Ladeira De Oliveira, Alice De Miranda Machado + Show 2 more

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https://doi.org/10.1155/2012/102915

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Abstract

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as diabetes mellitus (DM), could contribute to the coexistence of both lesions, and this possibility must be included in the medical investigation.

Highlights

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA) and necrobiosis lipoidica [1]
In 1979, Hanke et al used for the first time the nomenclature AEGCG, when described annular skin lesions associated with granulomatous elastolytic pattern [3]
Since the pathogenesis of AEGCG is not entirely understood, there is a possibility that cellular immunological reactions induced by modified function of elastic fibers’ antigenicity plays a role in the mechanism of AEGCG formation [8]

Summary

Introduction

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA) and necrobiosis lipoidica [1]. Lesions of AEGCG are mostly found in middle-aged white women, usually located on sunexposed areas and rarely on covered areas [2]. The chronic course of this disease is a typical feature as the variable response to existing treatments [4]. This case report is intended to describe and discuss a case of AEGCG, irresponsive to the treatment, associated with diabetes and rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA

Case Presentation

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Discussion