Abstract
Background: Hybrid Ameloblastoma is a rare type of ameloblastoma that is presently receiving attention in some quarters. Altogether, less than 30 cases have been reported in the scientific literature, thus calling for the need to report more cases in order to add to the body of knowledge on this lesion. This case report is aimed to add to the number of cases that are building up in the scientific literature. Materials and Methods: A 50-year-old female presented with a 3-year history of an anterior mandibular swelling extending from the body of the mandible on the right to the body of the mandible on the left. Orthopantomograph of the lesion revealed a mixed radiolucent and radiopaque lesion that extended from the distal region of the right mandibular second premolar to distal region of the left mandibular second molar. Segmental mandibulectomy with immediate replacement with reconstruction was undertaken. Results: Specimen which was subjected to histopathologic examination reported a diagnosis of Keratinizing Follicular Ameloblastoma and Desmoplastic Ameloblastoma with Osteoplasia, consistent with a diagnosis of Hybrid Ameloblastoma. There has been no sign of recurrence 7 months after a regular follow-up and the patient is planned for a long term follow-up. Conclusion: Besides histological details that combine both conventional ameloblastoma and desmoplastic ameloblastoma, the present case of hybrid ameloblastoma bears similar clinical features as well as treatment modalities to that of conventional solid multicystic ameloblastoma.
Highlights
Ameloblastoma is a benign odontogenic tumour of epithelial origin [1,2]
Less than 30 cases have been reported in the scientific literature, calling for the need to report more cases in order to add to the body of knowledge on this lesion
Specimen which was subjected to histopathologic examination reported a diagnosis of Keratinizing Follicular Ameloblastoma and Desmoplastic Ameloblastoma with Osteoplasia, consistent with a diagnosis of Hybrid Ameloblastoma
Summary
Ameloblastoma is a benign odontogenic tumour of epithelial origin [1,2]. It is found exclusively within the maxillofacial skeleton (intraosseous or centrally located) but has been reported to be located in the soft tissue (gingiva) overlying tooth bearing areas or alveolar mucosa in edentulous regions (extraosseous or peripherally located) [2]. Ameloblastoma is the most common odontogenic tumour [3], but its precise etiology till date remains unknown various etiologies have been postulated in the scientific literature [4,5]. It is the most commonly reported tumour in underdeveloped countries [6] with its highest prevalence recorded in Asian and African countries [7]. Ameloblastoma commonly presents radiologically as a unilocular or multilocular lesion [15] DA with osteoplasia and some cases of HA may present with the more unusual mixed radiolucent and radiopaque pattern similar to the radiological presentation of fibro-osseous lesions [15,16]. As far as we know, our case would be the 3rd documented Nigerian HA reported so far
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