Abstract

Bio-based and low-cost hybrid alginate–protein cryogel beads, which can be regenerated and reused, are efficient adsorbent materials for the purification of IgG from human serum.

Highlights

  • Significant advances in therapeutic applications have been achieved in the past decades with the use of antibodies or immunoglobulins (Igs) as biopharmaceuticals.[1]

  • Based on the possibility of using solid-phase extractions to purify immunoglobulin G (IgG), we focused on the development of bio-based and low-cost materials, namely hybrid cryogel beads composed of polysaccharides and proteins fibrils

  • This work aims to identify bio-based materials to be used in the purification of biopharmaceuticals, namely hybrid alginate-protein cryogel beads for the purification of IgG from human serum

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Summary

Introduction

Significant advances in therapeutic applications have been achieved in the past decades with the use of antibodies or immunoglobulins (Igs) as biopharmaceuticals.[1].

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