Abstract
Hybocarpone ( 1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone ( 1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone ( 1) was found to be a potent cytotoxin (IC 50 c 0.27 μM), active against the murine P815 mastocytoma cell line.
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