Abstract
Hyaluronidase revisited: A comparison of axillary plexus block with and without recombinant human hyaluronidase
Highlights
Hyaluronidase degrades hyaluronic acid, promoting the flow of drugs through tissue [1]
Block success rates for single-injection axillary plexus block were unaffected by the addition of 150U rHuPH20
It has been available as an additive to local anesthetic solutions since 1948
Summary
Hyaluronidase degrades hyaluronic acid, promoting the flow of drugs through tissue [1]. It has been available as an additive to local anesthetic solutions since 1948. There are a number of reasons to reassess its use. Few of these studies meet quality standards concerning the random allocation of treatment and a control group or blinded assessment of outcomes. Previous studies have tested animal-derived hyaluronidases which contain impurities which may influence the intended effect of the active ingredient [7]. RHuPH20 may be more effective in facilitating local anesthetic spread than the animal-derived preparations
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