Abstract
Mammalian blood contains a substance capable of inhibiting the activity of the enzyme hyaluronidase. In 1933 Duran-Reynals observed that the spreading factor quickly disappeared or lost its power when injected intravenously into rabbits. The inhibition of bacterial hyaluronidases by human and rabbit serum was demonstrated by Hobby, Dawson, Meyer & Chaffee (1941). McClean (1942) found that serum from various mammals incl. man inhibits testis hyaluronidases. This inhibitor is nonspecific in contrast to the antibody inhibitors which appear in the serum following previous contact with a hyaluronidase. The latter substances are specifically active against the foreign protein of the enzyme from a particular source (cf. Duran-Rey nals, 1942).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
