Hyaluronidase-1 expression is not a predictor of biochemical recurrence in radical prostatectomy specimens

Abstract

The purposes of this study were to evaluate the rate of biochemical recurrence among patients who underwent radical prostatectomy due to localized prostate cancer, assess the risk factors of biochemical recurrence, and investigate its relation with hyaluronidase-1 (HYAL-1). Materials and methods: We retrospectively evaluated the data of 112 patients who underwent radical retropubic prostatectomy. HYAL-1 expression was evaluated immunohistochemically and staining was graded as mild, moderate, and severe. Two blinded pathologists evaluated the specimens. The relation among preoperative pathologic findings that were detected in transrectal ultrasound (TRUS) guided biopsy, specimens of radical prostatectomy in the final stage, and biochemical recurrence rate were also evaluated. Mean follow-up time was 59.8 months (range: 20 to 92 months). Results: Tumor recurrence was detected in 29 patients. There was no relation between HYAL-1 expression and recurrence. In multivariate analysis, the percentage of tumors detected in TRUS biopsy specimens, positive surgical margin, capsular involvement, and seminal vesicle invasion detected in the final pathology were correlated with recurrence. The sensitivity, specificity, positive predictive value, and negative predictive value of HYAL-1 expression were respectively 38%, 63%, 30%, and 71%. Conclusion: HYAL-1 expression was not found to be predictive for recurrence. Further molecular markers and genetic studies are necessary to predict the biochemical recurrence after radical prostatectomy.