Hyaluronicase in intramuscular excretory urography.

Abstract

Intramuscular excretory urography (1, 7) is one of the simpler and easier methods of studying the upper urinary tract in children. With the discovery of hyaluronidase (6, 8), the “spreading factor,” extravascular administration of solutions has been facilitated (5). Several articles have appeared concerning the use of hyaluronidase in subcutaneous excretory urography (2, 3, 10). Since the technic of intramuscular is less difficult than that of subcutaneous urography (9, 11), the effect of hyaluronidase on the rate of absorption of Diodrast and Neo-Iopax administered intramuscularly was tested clinically. Technic Into one buttock we injected either Diodrast 35 per cent or Neo-Iopax 50 per cent2 in amounts varying from 6 to 10 c.c, plus 1 c.c. of 2 per cent procaine solution. Into the other buttock we injected the same mixture, to which had been added hyaluronidase in quantities from 150 to 750 TRU (turbidity reducing units). Thus each patient acted as his own control. Nine patients were tested in this mann...