Abstract
The current work was focused on formulation of new topical bioactive hyaluronic acid (HA)/Na-alginate (SA) films crosslinked with Ca2+, Zn2+, or Cu2+ metal cations. The antibacterial as well as some physico-mechanical properties of such crosslinked films such as gel fraction, swelling, tensile strength, stiffness, SEM, and water vapor permeability were discussed. Moreover, to enhance the antibacterial properties of the HA/SA/Ca2+ film, sulfadiazine (SD) alone or in combination with silver nanoparticles (AgNPs) as bioactive agents were incorporated in the formulation of that film. The in vitro releasing of sulfadiazine from such loaded film at different pH values was studied. The results obtained confirmed that among the above formulated films, the HA/SA/Ca2+/SD/Ag-NPs bio-film has the highest antibacterial activity. In addition, the above prepared films were screened as topical bioactive wound dressings for albino rats. The results indicated that both HA/SA/Ca2+/SD and HA/SA/Ca2+/SD/AgNPs films are effective dressings for restoring the homeostasis skin tissue of such rats to the normal control after 14 days, but the latter film was the best.
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