Abstract
To evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns. Systematic review of randomized controlled trials on the use of hyaluronic acid for the topical treatment of skin burns, based on recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected. They compared the application of hyaluronic acid 0.2% associated to silver sulfadiazine 1% 5g/cm2 versus silver sulfadiazine 1% 5g/cm2 alone for the outcome of complete healing. This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness. Avaliar a efetividade do ácido hialurônico na cicatrização de queimaduras de espessura parcial. Revisão sistemática de ensaios clínicos randomizados sobre a utilização de ácido hialurônico no tratamento tópico de queimaduras de pele, baseada nas recomendações do Cochrane Handbook for Systematic Reviews of Interventions. Foram recuperados dois ensaios clínicos randomizados que analisaram 143 pacientes portadores de queimaduras de espessura parcial e/ou espessura parcial profunda, comparando a aplicação de Ácido Hialurônico 0,2% associado à Sulfadiazina de Prata 1% 5g/cm2, versus Sulfadiazina de Prata 1% 5g/cm2 isolada, para o desfecho cicatrização completa. Esta revisão enfatiza a necessidade de novos ensaios clínicos randomizados bem delineados para estabelecimento da relevância terapêutica do ácido hialurônico no que tange à cicatrização de queimaduras de espessura parcial ou espessura parcial profunda.
Highlights
Wounds are defined as a solution of continuity of the skin or adjacent tissues originating from physical, chemical or thermal damage[1]
The objective of this review is to evaluate the effectiveness of hyaluronic acid in the healing of burns of partial thickness or deep partial thickness. This is a systematic review of randomized controlled trials based on the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions proposed by the Cochrane Collaboration
Fifteen articles were eliminated because they were experimental studies, five were in vitro studies, six assessed the treatment of corneal burns, two of the tympanic membrane, an application of intra-articular hyaluronic acid, an application of intra-abdominal hyaluronic acid, and a study about rhinoplasty
Summary
Wounds are defined as a solution of continuity of the skin or adjacent tissues originating from physical, chemical or thermal damage[1] The treatment of these injuries involves the use of covers, an advanced method[2] that uses products ideally obtained from biological components that are minimally handled, non-toxic, hypoallergenic and enable removal of the product without further tissue damage. The covers must provide a moist environment, promote gas exchange, prevent bacterial development, control excessive exudate[3], and maintain constant local temperature[4] without need for routine change[5]. In this context, hyaluronic acid stands out as a new technology for treating dermal and epidermal injuries. Hyaluronic acid has essential features to any biological coverage such as biocompatibility and biodegradability, plus it does not induce immunogenicity[7,8]
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