Abstract
Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.
Highlights
Cancer is a leading cause of death in the United States and numerous other parts of the globe.The new cancer cases worldwide are predicted to increase from approximately 14 million in 2012 to more than 22 million in 2030
The targeting efficiency of Hyaluronic acid (HA)-PB@quantum dot (QD) to lung cancer cells was enhanced by the coexistence of a magnetic core and cluster of differentiation 44 (CD44) ligand HA, which was found to significantly improve the specific uptake by CD44-overexpressed HeLa cells upon external theranosis (Figure 4)
HA-coated reduced graphene oxide (rGO) nanosheets were obtained by acid (CHA), which was synthesized using cholesteryl-2-aminoethylcarbamate (CAEC) with the carboxyl coating with cholesteryl hyaluronic acid (CHA), which was synthesized using cholesteryl-2group of HA [92]
Summary
Cancer is a leading cause of death in the United States and numerous other parts of the globe. Thesetreatment drugs administered body can act cancer anticancer there are various methods, into the the most basic of on which is cells or tissues byusing reducing cell viability or such expediting a specific(PTX), immune reaction for(DOX), the elimination chemotherapy anticancer drugs, as paclitaxel doxorubicin cisplatincancer It is necessary that administered drugs act on the cancerous tissue without affecting other normal cells and maintain a stable state in in vivo microenvironments until they are delivered.
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