Abstract
Purpose: Osteoarthritis (OA) is the most common joint disease, which is characterized by destruction of articular cartilage, osteophyte formation, synovitis, and subchondral bone changes. Pathological studies have indicated that in human OA cartilage, the hyaluronan (HA)-proteoglycan network is initially degraded and then collagen fibrils of type II and XI collagens are digested. Two hyaluronidases (HYAL1 and HYAL2) and a cell surface HA receptor CD44 were thought to be responsible for HA degradation.
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