Abstract
A mild chemical modification of hyaluronic acid (HA) provides functionalized derivatives for fabrication of targeted drug delivery systems, wound dressings, tissue engineering scaffolds, and probes for cellular binding and transport of HA. First, we describe the use of covalent HA-anti-cancer agents for use as potential therapeutics. Data from cell culture, flow cytometry, and in vivo mouse models support this targcted anti-tumor strategy. Second, we describe new flexible hydrogel films composed of crosslinked chondroitin sulfate (CS) and HA, which have potential as wound dressings capable of biointegration and drug release. Lyophilization and rehydration of these flexible films also provide porous materials for cell growth and tissue engineering. Third, we describe progress on the elucidation of the structure determination of the HA-binding domain (HABD) of RHAMM and the use of this domain to identify peptides that mimic HA.
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