Abstract
Hwangryunhaedok-tang Exerts Neuropreventive Effect on Memory Impairment by reducing Cholinergic System Dysfunction and Inflammatory Response in Vascular Dementia Rat Model
Highlights
Hwangryunhaedok-tang (HRT) in Korea, called Hwanglianjiedu-tang in China and Orengedokuto in Japan, is a traditional herbal formula comprising four medicinal herbs in a 1:1:1:1 ratio: PhellodendriCortex, Scutellariae Radix, Coptidis Rhizoma, and Gardeniae Fructus
EHRT, CHRT-2, or extract of Ginkgo biloba (EGB) administration resulted in dramatic increases in the number of surviving cells in the hippocampal subfields compared with numbers observed in the bilateral common carotid artery occlusion (BCCAO) group
Vascular dementia (VaD) is the second most common type of dementia caused by blocking blood flow to the brain tissue
Summary
Hwangryunhaedok-tang (HRT) in Korea, called Hwanglianjiedu-tang in China and Orengedokuto in Japan, is a traditional herbal formula comprising four medicinal herbs in a 1:1:1:1 ratio: Phellodendri. 22 of hypoperfusion is known to be a major cause of VaD, leading to cognitive impairment. Interestingly, several groups reported a cholinergic deficit in the cerebrospinal fluid and brain that several groups reported a cholinergic deficit in the cerebrospinal fluid and brain that may be associated may be associated with the pathogenesis of VaD [10,11,12]. Cholinergic drugs such as with the pathogenesis of VaD [10,11,12]. Acetylcholinesterase (AChE) inhibitors are suggested as promising therapies for VaD [13]. In this study, investigated the therapeutic effects of HRT on VaD using a bilateral common carotid artery occlusion we investigated the therapeutic effects of HRT on VaD using a bilateral common carotid artery occlusion (BCCAO) rat model by assessing spatial memory impairment and activation of neuroinflammation
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