Abstract
This article deals with a Windows (© Microsoft Inc.) executable, user-friendly program that tests the hypothesis of Hardy-Weinberg (HW) proportions from autosomal multiallelic data using different methods that include parametric, nonparametric and exact bootstrap tests, the latter obtained through computer simulations. The program can be obtained free of charge directly from the internet repository https://github.com/Lemes-RenanB/HardyWeinbergTesting.
Highlights
In spite of its old age, the testing of Hardy-Weinberg proportions still is a kind of warhorse/cornerstone in population genetics
The test is used extensively on a routine basis to exclude samples with gross molecular typing defects from the usually very large sets of genetic markers presently used in various types of population genetic analyses
An in-depth analysis of the available computer programs for population genetics analysis is found in Excoffier and Heckel (2006), a review that certainly should be consulted in spite of being a bit outdated as to the program’s versions
Summary
In spite of its old age, the testing of Hardy-Weinberg proportions still is a kind of warhorse/cornerstone in population genetics. There exist many good population genetics programs, freely available in the internet; among other tasks, they provide adequate chi-squared and exact (computer simulated) testing for Hardy-Weinberg proportions.
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