Hutchinson Gilford Progeria Syndrome with Ocular Manifestation

Abstract

Hutchinson Gilford progeria Syndrome (HPGS) was first described by Jonathan Hutchinson Gilford in 1897 [1]. It is characterized by characteristic facies also described as plucked bird appearance. These are reported to occur due to denovo autosomal dominant mutation in Laminin A(LMNA) gene present on 1q21.1-1q 21.3 and are rarely inherited [2]. This is to report a rare case series of two children presenting with Hutchinson Gilford progeria with ocular manifestation.