Abstract
Huntington's disease (HD) is a neurological disorder characterized by severe movement disorders, dementia and widespread neuronal degeneration in the corpus striatum and cerebral cortex. In the caudate and putamen there was a significant decrease in GABA receptor binding in HD. In the frontal cortex, GABA receptors were not altered in this disorder. In the HD putamen, both BDZ receptor density and the affinity of BDZ receptors for 3H-flunitrazepam decreased. In the HD frontal cortex and cerebellum, only an increase in receptor density was detected. The results of the present study suggest that striatal GABA receptors and BDZ receptors are lost in HD. The affinity charges of BDZ receptors found in the HD putamen are probably associated with the lower levels of GABA found in that region and the increases in BDZ receptors in the cerebellum and cortex may be related to decreases in the levels of some endogenous substance that acts upon these receptors.
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