Abstract
This article overviews Huntington’s Disease (HD), emphasizing the development of neuroimaging biomarkers, pathogenesis discovery, and clinical treatment. The fundamental knowledge of HD includes its definition, diagnosis as an etiological subtype of neurodegenerative diseases in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), clinical neuropsychiatric symptoms, and social impact. The development of neuroimaging biomarkers is discussed with different developmental stages of HD. Mental health issues in the HD population including depression, anxiety, and psychosis were reviewed. The suicidal rate in this population is alarming, indicating the necessity to make both medical and mental health services available. Clinical treatments, including pharmacological and non-pharmacological, are overviewed with the timeline from now till the future. Recommendations are given for refining current research and future research design regarding neuroimaging biomarker exploration, early diagnosis, and potential treatment investigation. This review can provide some guidance to the development of more advanced diagnostic tools and effective treatments for this population.
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