Hunger in humans induced by MK-329, a specific peripheral-type cholecystokinin receptor antagonist

Abstract

Since cholecystokinin (CCK) was discovered in 1928 (Ivy and Oldberg 1928) numerous stud.~es have sought to determine its physiological function in animals and in humans. These investigations have been complicated by the subsequent discovery of different types of CCK receptors, subclassified as the peripheral ( ty~ A) and central (type B) CCK receptors (Moran et al. 1986; Dourish and Hill 1987). Although located primarily in the digestive system, peripheral-type receptors are also found in the centrai aervous system, in ,~ species-specific distfibution (Mor~n et ~1. 1986; Hill et al. 1987). The recent development of CCK receptor antagonists ~eieetive for the peripheral-type receptor, e.g., MK-329 (previously named L364,718 [3S(-)-N-(2,3-dihydro-l-methyl-2oxo-5-phenyi-l-H-i, 4~b~,nzodiazepine-3-YL)1H ind01e-2-carbox~oe_o (Evans et al. 1986;