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Abstract
Humulus Scandens has been widely used for a long time in folk medicine, but it has not been systematically researched until now. The aims of this study were to isolate the components and simultaneously determine the contents of luteolin-7-O-β-D-glucoside (LGL) and apigenin-7-O-β-D-glucoside (AGL) in the different parts of H. Scandens. At the same time, our research team verified the anti-cancer activity and the alveolar fluid clearance (AFC) of H. Scandens total flavonoids (HSTF), LGL and AGL. The anti-cancer experiment showed that HSTH and LGL have a significant inhibition effect on the HepG2 cell. The cell viability decreased when drug concentration increased, but AGL has an indistinctive effect on HepG2 cell under the same concentration. The AFC experiment showed that AFCs of HSTF, LGL and AGL, compared to the blank control group, increased, which explained the H. Scandens pharmacological effect of removing edema. This result provides the theoretical basis for H. Scandens clinical application.
Highlights
The whole herb of Humulus Scandens (Lour.) Merr. listed in the medical literature in Tang Ben Cao, is effective in reducing heat, detoxicating, treating diuresis and promoting detumescence. It has been widely used for a long time in folk medicine [1]
Flavonoids have been confirmed by various studies to possess a wide range of pharmacological action, especially in antioxidation [4,5], anti-inflammation [6], prevention of coronary heart disease [7], anti-HIV pharmacological action [8] and inhibition of tumor promotion effects [9]
Our previous experiment results showed [11] that the best seasons for collections were from Jun. through Aug. so we collected the materials in August and divided them into different parts: root, stem, leaf and petiole
Summary
The whole herb of Humulus Scandens (Lour.) Merr. listed in the medical literature in Tang Ben Cao, is effective in reducing heat, detoxicating, treating diuresis and promoting detumescence. Listed in the medical literature in Tang Ben Cao, is effective in reducing heat, detoxicating, treating diuresis and promoting detumescence. It has been widely used for a long time in folk medicine [1]. Scandens with a strong vitality can adapt to the hardy soil texture and climate conditions of the ecological environment at an altitude of 500-1500m of barren hills, valleys, woodland and is widely distributed in northern temperate and subtropical zones, primarily in China, Korea and Japan [2] It can be found in great abundance in nature and contains multiple flavonoids. Flavonoids have been confirmed by various studies to possess a wide range of pharmacological action, especially in antioxidation [4,5], anti-inflammation [6], prevention of coronary heart disease [7], anti-HIV pharmacological action [8] and inhibition of tumor promotion effects [9]
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