Abstract
This chapter discusses a study of humoral regulation of sleep and wakefulness by hypnogenic and activating dialysable factors. Dialysis of cerebral venous blood was performed on rabbits during sleep induced by electrical stimulation of the medio-central intralaminary thalamus, or during sustained wakefulness elicited by stimulation of the activating reticular system in the midbrain. From the whole dialysate (30 ml) obtained during 80 min from the stimulated donor animal, 20 ml were injected intravenously to normal free-moving animals (recipient). The latters' behavior was filmed and analyzed with a kinesimeter, and the electrical brain activity was continuously recorded. The results showed that injection of dialysate from a sleeping donor elicits in the recipient a moderate sleep, which does not differ in behavior and electroencephalogram (EEG)from normal sleep. The action of dialysate from sleeping donors is significantly different from that of control donors after sham-stimulation of the thalamus. Injection of dialysate from alert donors elicits a behavioral and electrographic arousal with numerous symptoms of rhinodiencephalic type. These sleep and arousal effects induced in the recipients by injection of dialysate from sleeping or alert donors suggest that dialysable humoral factors play a role in the mediation of sleep and wakefulness.
Published Version
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