Abstract
To the Editor: In their review article on humoral innate immunity, Mantovani and Garlanda (Feb. 2 issue)1 do not mention the mast cell, a unique tissue immune cell that is considered to be the master orchestrator of the immune response by secreting numerous proinflammatory molecules, especially chemokines and cytokines.2 With respect to Covid-19, mast cells were found to be degranulated in the lungs of deceased patients with severe disease.3,4 Other investigators have reported elevated serum levels of the mast cell–derived proteolytic enzymes chymase and tryptase in patients with Covid-19.5,6 Our own preliminary results show that nanomolar levels of recombinant full-length .
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