Abstract
In sera of 17 adult patients with clinically and bacteriologically documented gram-negative septic shock, IgG and IgM antibody concentrations to various rough lipopolysaccharide (R-LPS) antigens (J5-LPS, Re-LPS, Lipid A), to a mixture of smooth (S-) LPS preparations and to the gram-negative bacterial strain that caused the septic shock, were measured in quantitative ELISA. Antibody concentrations were expressed as proportional to the total IgG (for IgG antibodies) or the total IgM concentration (for IgM antibodies) and compared with the antibody concentrations to the corresponding LPS and gram-negative bacterial antigens in sera of non-infected controls ( n=28). It was shown that gram-negative septic shock was associated with decreased total IgG and IgM concentrations (46% and 52% respectively of the mean concentration in control sera, P < 0·01) and with specifically decreased IgG antibody concentrations to Re-LPS and Lipid A (per mg total IgG ml −1: 31% and 71% respectively of the mean concentration in control sera, P < 0·001 and P < 0·05 respectively).
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