Abstract
ABSTRACT Pig stable dust may contain large amounts of potentially allergenic pig urinary proteins (PUP). In this study, inhibition enzyme immunoassays were used to measure airborne PUP expo-sure, and high levels (up to 200 μgeq/m3) could indeed be demon-strated in personal inhalable dust samples of pig farmers. IgE and IgG4 anti-PUP were assessed in the sera of 191 pig farmers, for whom also questionnaire and bronchoprovocation data were avail-able. IgE anti-PUP was found in only 5-7%, and was at best weakly associated with respiratory symptoms. In contrast, IgG4 anti-PUP was found in many subjects, and titres were negatively associated with respiratory health problems, and also with bronchial hyperreac-tivity to histamine. Anti-PUP IgG4 antibodies thus seem to protect pig farmers from developing respiratory symptoms and BHR.
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