Abstract
The existence of a humoral factor circulating in blood and controlling feeding behavior was studied in sheep. Blood from the jugular veins of hungry and satiated sheep was exchanged at a rate of 70 ml per min during 1 hr by a pump-controlled cross-circulation. During the cross-circulation period plus the following 15 min feed consumption of satiated sheep was increased 48% over control values (p<0.05). One-hr feed consumption of hungry sheep feed-deprived for 6 hr until the end of the blood exchange, was decreased 17% (p<0.05) when compared with control values. Auditory canal temperature was not affected. These results provide evidence of a humoral factor present in blood of sheep controlling feeding behavior.
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