Abstract
During inflammatory reactions induced in mice by an intraperitoneal injection of particulate substances the number of peritoneal macrophages increases and a monocytosis occurs. The regulation of this increase of mononuclear phagocytes in the tissues and circulation has been investigated. It has been demonstrated that serum of these mice contains a factor increasing monocytopoiesis (FIM). FIM could be demonstrated during the early phase of an acute or chronic inflammatory reaction. The highest level was always reached before the highest number of peripheral blood monocytes was attained, indicating that this factor acts on monocyte precursors. FIM has been shown to increase monocyte production by reducing the cell—cycle time of the promonocytes and increasing the number of these cells; there is evidence that FIM also affects the mitotic rate of the monoblasts.
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