Humoral and cellular immunoresponsiveness of stanchioned cattle infested with Psoroptes ovis

Abstract

Bovine scabies in a clinical problem during the cool autumn and cold winter months. In south Texas it is necessary to stanchion animals in order to elicit patent infestation during summer months. Environmental factors and grooming have been purported to account for summer resistance to infestation. However, stanchioned animals exhibit varied levels of susceptibility to infestation, suggesting that the noted variability may be influenced by the host immune response. In this study, animals were infested with Psoroptes ovis while in stanchions. The development of anti- P. ovis antibody activity was measured by the enzyme-linked immunosorbent assay and cellular immune function was monitored with mitogens and P. ovis antigens. A correlation was noted between the development of anti- P. ovis antibody activity and the increase in mite numbers and dermatitis. Coincident with the developing infestation was a suppression of T-cell function that appeared to be stress-related as a result of stanchioning. A working hypothesis is presented that attempts to correlate the developing humoral response and the depressed T-cell response with both an increasing dermatitis and mite population.