Abstract
Abstract Humiria balsamifera is used in traditional medicine as anthelmintic, expectorant, to treat hepatitis, diarrhea, hemorrhoids; to cure chronic wounds; and to alleviate toothaches. This species occurs in Jurubatiba shoal, Rio de Janeiro state-Brazil, a rich region which offers a variety of promising bioactive product sources. The present study focuses on the chemical and pharmacological evaluation of H. balsamifera. The n-hexane, dichloromethane and ethyl acetate leaf fractions exhibited higher inhibitory potential on NO production. Friedelin (1), quercetin (2) and quercetin-3-α-O-arabinopyranoside (3) were isolated and characterized; the latter is described for the first time for H. balsamifera. Quercetin (2) showed the best inhibitory activity on NO production and moderate inhibition of TNF-α production. These results contribute to the knowledge of Humiria balsamifera as a source of anti-inflammatory compounds. Furthermore, the identification of the terpenes ß-amyrone, betulin, citronellol, eremophillene, dihydroactinolide and borneol, and the isolation of quercetin-3-α-O-arabinopyranoside are being reported for the first time for this species.
Highlights
Humiria balsamifera is used in traditional medicine as anthelmintic, expectorant, to treat hepatitis, diarrhea, hemorrhoids; to cure chronic wounds; and to alleviate toothaches
Considering the importance of plants as alternative sources for obtaining new antiinflammatory bioactive constituents (Bernstein et al 2018), this paper proposes to study Humiria balsamifera Aubl
Humiria balsamifera is popularly used in the Amazon as a perfume and in the treatment of diseases such as hepatitis, diarrhea and hemorrhoids (Coelho-Ferreira 2009)
Summary
Humiria balsamifera is used in traditional medicine as anthelmintic, expectorant, to treat hepatitis, diarrhea, hemorrhoids; to cure chronic wounds; and to alleviate toothaches This species occurs in Jurubatiba shoal, Rio de Janeiro state-Brazil, a rich region which offers a variety of promising bioactive product sources. Quercetin (2) showed the best inhibitory activity on NO production and moderate inhibition of TNF-α production These results contribute to the knowledge of Humiria balsamifera as a source of anti-inflammatory compounds. Its use has been described as anthelmintic, expectorant, healing action against toothache and chronic wounds (Lorenzi & Matos 2008) Considering some of these popular applications, such as for the treatment of hemorrhoids and toothache, it may be directly related to the modulation of the inflammatory process, so, the evaluation of this species in terms of its anti-inflammatory potential became relevant. The combination of several physical and chemical factors of this region, such as high temperature, salinity and high exposure to light (CogliattiCarvalho et al 2001; Kelecom et al 2002) makes it a promising source in the search for new bioactive products and evidencing the importance of its preservation
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