Abstract
A 24-year-old healthy male patient with a history of taking human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) presents after a fall of 15 feet with a displaced, comminuted mid-shaft humerus fracture treated with open reduction internal fixation with a lateral plate. The patient initially had an uneventful postoperative course but experienced an atraumatic increase in arm pain with radiographs consistent with nonunion and plate fatigue fracture requiring revision after eleven months. Humeral shaft nonunion in an otherwise healthy male patient taking HIV PrEP suggests these medications may be a risk factor for nonunion. However, additional studies with sufficient statistical power are required to define this interaction further and better understand the clinical implications.
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