Abstract
We describe a PCR-confirmed case of Plasmodium knowlesi infection with a high parasitemia level and clinical signs of severe malaria in a migrant worker from Malaysian Borneo in the Netherlands. Investigations showed that commercially available rapid antigen tests for detection of human Plasmodium infections can detect P. knowlesi infections in humans.
Highlights
Unlike P. malariae, which multiplies every 3 days in the blood and never results in severe infections, P. knowlesi multiplies daily, and high parasitemia with death in humans can occur [4]
We describe a PCR-confirmed case of Plasmodium knowlesi infection with a high parasitemia level and clinical signs of severe malaria in a migrant worker from Malaysian Borneo in the Netherlands
We report a case of imported P. knowlesi infection in the Netherlands in a migrant worker from Malaysian Borneo
Summary
Unlike P. malariae, which multiplies every 3 days in the blood and never results in severe infections, P. knowlesi multiplies daily, and high parasitemia with death in humans can occur [4]. This P. knowlesi infection was detected by commercially available rapid diagnostic antigen tests for malaria. In a rapid diagnostic test for malaria (BinaxNOW Malaria Test; Binax, Inc., Scarborough, ME, USA), his blood sample was negative for P. falciparum histidine-rich protein 2 but showed a positive reaction with pan-malarial aldolase antigen, which suggested a non–P. falciparum infection.
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