Humanistic Care Nursing Mode for Severe Hyperbilirubinemia Patients Who Undergoing Double Plasma Molecular Adsorption System and Plasma Exchange

Rou Wen,Yanyun Chen,Zhaolin Chen

doi:10.11648/j.ajns.20200903.16

Abstract

Objective: To assess humanistic care nursing mode for severe hyperbilirubinemia patients who undergoing double plasma molecular adsorption system and plasma exchange. Methods: 124 participants were diagnosed with severe hyperbilirubinemia and were received combined treatment, include that double plasma molecular adsorption system and Plasma exchange. They were randomly assigned to control group (n = 62) and intervention group (n = 62). We collect the participant information by Self-Rating Anxiety Scale, Self-rating depression scale and the Short Form-36. The information include the satisfaction of patients, anxiety status, depression status and quality of life. Result: In patient satisfaction research, the intervention group has more very good level assessment than that of control group (41 vs 32). Also, control group has more good level assessment than that of intervention group (18 vs 8). In anxiety and depression research, intervention group has better improvement in anxiety status, it is from 56.4±6.7 to 45.3±5.1. In quality of life research, the intervention group has greater improvement than that of control group in every domain. Conclusion: humanistic care nursing mode provide better improvement in mental health aspect of patient. It significantly improved anxiety and depression, and improved overall quality of life after treatment.

Highlights

The incidence of hyperbilirubinemia is high clinically, which is in some cases difficult to cure by medication, surgery or interventional therapies [1]
The patient satisfaction information from a simple interview, we provide a choice of satisfaction assessment which have 5 levels in assessment to participants
Plasma exchange has proven effective in several autoimmune diseases, such as Guillain-Barre syndrome, idiopathic thrombocytopenic purpura and myasthenia gravis [14, 15]

Summary

Introduction

The incidence of hyperbilirubinemia is high clinically, which is in some cases difficult to cure by medication, surgery or interventional therapies [1]. More accurate prediction of severe hyperbilirubinemia by combining the predischarge bilirubin level with clinical risk factors assessment than the use of either method alone and using various methods such as the prediction model or graphic tools [5, 6]. Plasma exchange removes bilirubin, endotoxin and complement activators, and replenishes albumin, coagulation factors and hepatic regenerative stimulating substance, which can correct metabolic disorder [7]. Plasma exchange has been regarded as the standard escalation therapy, based on one randomised, sham-controlled study in 22. The double plasma molecular adsorption system is a new adsorption therapy in hyperbilirubinemia treatment. Base on traditional bilirubin adsorption therapy, the double plasma molecular adsorption system has an additional broad-spectrum adsorption column, it include neutral macroporous adsorption resin and ion exchange resin. Its functions are can adsorb medium-molecular toxins, and absorb macro-molecular toxins in treatment process [10]

Participants Enrollment and Study Methods

Result

Findings

Discussion