Abstract
Depression and anxiety are well-recognized comorbid health conditions among adults with migraine due to their humanistic and economic burden. This review was conducted to systematically assess the humanistic and economic burden of comorbid depression and/or anxiety disorder among adults with migraine. A systematic literature search was conducted using MEDLINE and CINAHL via EBSCO, EMBASE, and Cochrane Database of Systematic Reviews via OVID. Studies evaluating the humanistic burden and the economic burden of comorbid depression and anxiety among adults with migraine that were published in peer-reviewed English language journals from inception until January 2020 were included. Out of the 640 identified articles, 23 studies were found eligible and included in this review. Regarding the humanistic burden, health-related quality of life (HRQoL) was examined by 11 studies, 7 studies examined disability, while 2 studies evaluated both HRQoL and disability measures. These studies reported an association between depression and/or anxiety and lower HRQoL and higher disability among adults with migraine. Regarding the economic burden, only three studies were identified and all concluded that depression and/or anxiety are significantly associated with higher healthcare expenditures and utilization among adults with migraine. Results of this review highlight the substantial burden of depression and/or anxiety for adults with migraine. Healthcare providers need to identify and treat anxiety and depression for patients living with migraine.
Highlights
Depression and anxiety are highly prevalent disabling chronic conditions among adults with migraine
Twelve studies reported an association between depression and/or anxiety and lower Health-Related Quality of Life (HRQoL) and seven studies reported an association between depression and/or anxiety and higher disability
These results of this review highlight the substantial impact of depression and/or anxiety on HRQoL, disability, healthcare cost and utilization of medical services for adults with migraine
Summary
Depression and anxiety are highly prevalent disabling chronic conditions among adults with migraine. Depression and anxiety are highly prevalent among adults with migraine. Adults with migraine are two to four times more likely to suffer from depression and anxiety compared to adults in the general population [1,2,3,4]. Coexisting depression and anxiety among adults with migraine are a major clinical problem but they are associated with higher disability [7], and poor Health-Related Quality of Life (HRQoL)[1, 7, 8]. A population-based studies in the United States (U.S.) and the United Kingdom reported that subjects with migraine have a significantly lower score of HRQoL in two domains; the mental and physical health component scores due to comorbidity of migraine and depression that each exerts a significant effect on HRQoL [1]
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