Abstract
OBJECTIVE: The mechanisms of sperm binding to the zona pellucida (ZP) of ovulated eggs remain unclear. Mouse models are often used to study sperm-egg recognition, but the mouse zona contains three proteins (ZP1, ZP2, ZP3) whereas the human zona contains four (ZP1, ZP2, ZP3, ZP4). Human sperm are fastidious and bind to human but not mouse eggs. We sought to determine if human ZP4 expressed in transgenic mice would be sufficient to support human sperm binding and provide an explanation of the observed taxon-specificity of fertilization.
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