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Abstract
Hepatic fibrosis is considered a worldwide public health problem. Liver transplantation is the treatment of choice. Rejection, post-operative complications and unavailability of donors are major obstacles. Recent treatment modalities include cell therapy but more researches are still needed. Human umbilical cord blood is a rich source for mononuclear cells which recently have shown promising anti-fibrotic results. The present study aimed to evaluate the potential effect of human umbilical cord blood mononuclear cells infusion on an experimental model of hepatic fibrosis caused by Schistosoma mansoni. Assessment of liver fibrosis was done by haematoxylin, eosin and Masson's trichrome staining. Homing to injured liver was assessed by staining of human specific nuclear antigen. Liver functions, collagen and hepatic stellate cells staining were done. Our results revealed marked improvement of liver fibrosis raising the possibility for the mononuclear cells clinical use in patients with hepatic fibrosis.
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