Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.

Abstract

Aim: To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. Methods: We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCsand hUCMSCs combined with SIS. We monitored wound healing, scoresand area, and analyzed inflammatory cells, microvessel densityand collagen fibers after 12days. Results: The blank group showed no healing, forming a scar of 0.6×0.5cm2, while SIS and hUCMSCs groups exhibited incomplete healing with 0.4×0.5cm2 scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. Conclusion: Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.