Human umbilical cord blood hematopoietic stem cell expansion by the RNA-binding protein Musashi-2.

Abstract

Transplantation of hematopoietic stem and progenitor cells (HSPC) is often the only curative therapy available for patients with high-risk leukemias or other hematologic cancers (Nikiforow and Ritz, 2016). The two major sources to obtain HSPC for transplantation are from the bone marrow or peripheral blood of a donor (Negrin, 2016b). For allogeneic HSPC transplantation, human leukocyte antigen (HLA) matching between recipient and donor is essential but only 20-30% of these patients have HLA-matched sibling donors (Nikiforow and Ritz, 2016, Negrin, 2016a). This article is protected by copyright. All rights reserved.