Abstract
Tonal preference distributions were measured in volunteers, before and after the ingestion in double-blind conditions, of 5, 10, 20, and 40 mg of δ 8-tetrahydrocannabinol ( δ 8-THC), an active constituent of marihuana, and placebo. Placebo and 5 mg of δ 8-THC did not change the typical inverted U-shaped distribution of preferences as function of sound frequency. At higher dosages there was a reliable tendency towards preference for the highest pitched tones, and in a few cases, a disruption of the responses. Increase in pulse rate, alterations in time production tasks and subjective effects were other actions of the higher dosages of the drug. Those data confirmed previous reports.
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