Abstract
ABSTRACT In 9% of a series of 160 thyroid tumors (130 malignant and 30 benign), the only or the predominant cell type was the oxyphilic Hurthle cell. Three carcinomas (follicular or papillary) and two adenomas were evaluated by histochemical, electron microscopic and biochemical techniques. The characteristic cytological features were: cytoplasm loaded with mitochondria of relatively normal structural architectonics, and an increased number of cytoplasmic dense bodies which possessed acid phosphatase and nonspecific esterase activities and therefore could be classified as lysosomes. The mitochondria isolated from Hurthle cell tumors contained higher than normal activity of succinoxidase and cytochrome oxidase and exhibited normal difference spectrum. One follicular carcinoma and one follicular adenoma contained considerable amounts of a poorly iodinated thyroglobulin. When studied, the peroxidase and iodination activities were present but lower than normal. The subcellular distribution of perioxidase and ...
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